Raposa T, Várkonyi J, Gráf F
Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(2):180-5.
A register of 746 cases of secondary acute leukemias has been established by reviewing the literature from 1930-1980. Out of these 680 belong to acute nonlymphocytic leukemias, FAB M1-M6. Data have been subjected to a multiparameter analysis in term of previous therapy and subtype characteristics of acute nonlymphocytic leukemia (ANLL). There are indications that secondary ANLL are characterized by the preponderance of early acute myeloblastic leukemias if compared to de novo ones. Furthermore it has been shown that alkylating agents induced decidedly more acute myelomonocytic leukemias whereas irradiation tended to induce more acute myeloblastic leukemia. Since secondary acute leukemias represent a serious late consequence of alkylating agent and irradiation therapy it is high time to find new therapeutical modalities for lymphomas and to consider the withdrawal of alkylating agents from the therapy of autoimmune disorders.
通过回顾1930年至1980年的文献，建立了一个包含746例继发性急性白血病的登记册。其中680例属于急性非淋巴细胞白血病，FAB M1 - M6型。已根据先前的治疗方法以及急性非淋巴细胞白血病（ANLL）的亚型特征对数据进行了多参数分析。有迹象表明，与原发性急性非淋巴细胞白血病相比，继发性急性非淋巴细胞白血病的特征是早期急性髓细胞白血病占优势。此外，研究表明烷化剂明显诱发更多的急性粒单核细胞白血病，而放疗则倾向于诱发更多的急性髓细胞白血病。由于继发性急性白血病是烷化剂和放射治疗严重的晚期后果，因此现在是时候寻找治疗淋巴瘤的新方法，并考虑在自身免疫性疾病治疗中停用烷化剂了。
