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单克隆抗体：技术及其在革兰氏阴性菌感染中的应用

Monoclonal antibodies: technology and application to gram-negative infections.

作者信息

Young L S

出版信息

Infection. 1984 Jul-Aug;12(4):303-8. doi: 10.1007/BF01645970.

DOI:10.1007/BF01645970
PMID:6208152
Abstract

Monoclonal antibodies have obvious diagnostic and therapeutic applications in infectious diseases. The technology for producing these highly specific reagents is readily available and we have produced monoclonal antibodies against the core glycolipid (endotoxin) region of gram-negative bacilli and the O-antigens of Pseudomonas aeruginosa. These antibodies are protective by different mechanisms and more than one antibody against a bacterium may give enhanced protection. Use of antibodies plus antimicrobial therapy may yield optimal results.

摘要

单克隆抗体在传染病的诊断和治疗方面具有显著应用。生产这些高度特异性试剂的技术容易获得，并且我们已经生产出了针对革兰氏阴性杆菌核心糖脂（内毒素）区域以及铜绿假单胞菌O抗原的单克隆抗体。这些抗体通过不同机制发挥保护作用，针对一种细菌使用多种抗体可能会增强保护效果。联合使用抗体和抗菌疗法可能会产生最佳效果。

相似文献

1
Monoclonal antibodies: technology and application to gram-negative infections.单克隆抗体：技术及其在革兰氏阴性菌感染中的应用
Infection. 1984 Jul-Aug;12(4):303-8. doi: 10.1007/BF01645970.
2
Monoclonal antibodies: technology and application to gram-negative infections.单克隆抗体：技术及其在革兰氏阴性菌感染中的应用
Infection. 1985;13 Suppl 2:S224-9. doi: 10.1007/BF01644435.
3
Monoclonal antibodies for treatment of gram-negative infections.用于治疗革兰氏阴性菌感染的单克隆抗体。
Rev Infect Dis. 1989 Nov-Dec;11 Suppl 7:S1564-71. doi: 10.1093/clinids/11.supplement_7.s1564.
4
Production and characterisation of mouse monoclonal antibodies reacting with the lipopolysaccharide core region of gram-negative bacilli.
J Med Microbiol. 1988 Jun;26(2):107-14. doi: 10.1099/00222615-26-2-107.
5
Treatment of experimental gram-negative bacterial sepsis with murine monoclonal antibodies directed against lipopolysaccharide.用针对脂多糖的鼠单克隆抗体治疗实验性革兰氏阴性菌败血症。
Surgery. 1989 Aug;106(2):147-54; discussion 154-5.
6
[Lipopolysaccharides, endotoxins and O-antigens of gram-negative bacteria: chemical structure, biologic effect and serologic properties].[革兰氏阴性菌的脂多糖、内毒素和O抗原：化学结构、生物学效应及血清学特性]
Infection. 1987;15 Suppl 2:S76-84. doi: 10.1007/BF01644198.
7
Antibodies to lipopolysaccharides: some diagnostic and protective aspects.抗脂多糖抗体：一些诊断和保护方面
APMIS Suppl. 1990;18:1-38.
8
Production and characterization of monoclonal antibodies against serotype strains of Pseudomonas aeruginosa.抗铜绿假单胞菌血清型菌株单克隆抗体的制备与鉴定
Infect Immun. 1987 May;55(5):1051-7. doi: 10.1128/iai.55.5.1051-1057.1987.
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Monoclonal antibodies that distinguish inner core, outer core, and lipid A regions of Pseudomonas aeruginosa lipopolysaccharide.可区分铜绿假单胞菌脂多糖内核、外核和脂质A区域的单克隆抗体。
J Bacteriol. 1994 Dec;176(23):7129-39. doi: 10.1128/jb.176.23.7129-7139.1994.
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Generation of a protective human monoclonal for the treatment of gram-negative sepsis.生成用于治疗革兰氏阴性败血症的保护性人源单克隆抗体。
Prog Clin Biol Res. 1988;272:383-93.

引用本文的文献

1
Monoclonal antibodies and immobilized antibodies. Patents and literature.单克隆抗体与固定化抗体。专利及文献。
Appl Biochem Biotechnol. 1985 Jun;11(3):233-48. doi: 10.1007/BF02798479.
2
Endotoxin inactivation in plasma from septic patients: an in vitro study.
World J Surg. 1986 Apr;10(2):318-23. doi: 10.1007/BF01658154.
3
Immunoprophylaxis and immunotherapy of gram-negative sepsis and shock with antibodies to core glycolipids and lipid A of bacterial lipopolysaccharides.用针对细菌脂多糖核心糖脂和脂质A的抗体对革兰氏阴性菌败血症和休克进行免疫预防和免疫治疗。

本文引用的文献

1
Preparation of monoclonal antibodies: strategies and procedures.单克隆抗体的制备：策略与程序
Methods Enzymol. 1981;73(Pt B):3-46. doi: 10.1016/0076-6879(81)73054-4.
2
Protective human hybridoma antibody to tetanus toxin.破伤风毒素的保护性人杂交瘤抗体。
J Clin Invest. 1982 Dec;70(6):1306-9. doi: 10.1172/jci110730.
3
Cooperative immunoassays: ultrasensitive assays with mixed monoclonal antibodies.合作免疫测定法：使用混合单克隆抗体的超灵敏测定法。
Infection. 1991 Nov-Dec;19(6):383-90. doi: 10.1007/BF01726444.
Science. 1983 Jul 15;221(4607):279-81. doi: 10.1126/science.6857284.
4
Functional properties of anti-group B streptococcal monoclonal antibodies.抗B族链球菌单克隆抗体的功能特性
Clin Immunol Immunopathol. 1982 Sep;24(3):342-50. doi: 10.1016/0090-1229(82)90005-8.
5
Monoclonal antibodies against Pseudomonas aeruginosa outer membrane antigens: isolation and characterization.抗铜绿假单胞菌外膜抗原的单克隆抗体：分离与鉴定
Infect Immun. 1982 Jul;37(1):166-71. doi: 10.1128/iai.37.1.166-171.1982.
6
Serological classification of Neisseria gonorrhoeae with monoclonal antibodies.用单克隆抗体对淋病奈瑟菌进行血清学分类
Infect Immun. 1982 Jun;36(3):1042-53. doi: 10.1128/iai.36.3.1042-1053.1982.
7
Immunological properties of monoclonal antibodies specific for meningococcal polysaccharides: the protective capacity of IgM antibodies specific for polysaccharide group B.
J Gen Microbiol. 1983 Aug;129(8):2451-6. doi: 10.1099/00221287-129-8-2451.
8
Structure of the Core oligosaccharide from the lipopolysaccharide of Pseudomonas aeruginosa PAC1R and its defective mutants.铜绿假单胞菌PAC1R脂多糖核心寡糖的结构及其缺陷突变体
Eur J Biochem. 1983 May 2;132(2):329-37. doi: 10.1111/j.1432-1033.1983.tb07366.x.
9
Antibody producing human-human hybridomas. I. Technical aspects.产生抗体的人-人杂交瘤。I. 技术方面。
J Immunol Methods. 1983 Jun 24;61(1):17-32. doi: 10.1016/0022-1759(83)90004-2.
10
Tumor therapy with monoclonal antibodies.单克隆抗体肿瘤治疗
Fed Proc. 1983 Jun;42(9):2650-6.