Raine C S, Mokhtarian F, McFarlin D E
Lab Invest. 1984 Nov;51(5):534-46.
The fine structure is described of a new model of chronic relapsing experimental allergic encephalomyelitis in the SJL/J mouse induced by the single adoptive transfer of myelin basic protein-sensitized lymph node cells. The neuropathology of the condition compared favorably with that seen in other species, and unlike a similar disease in the same strain of mouse induced by active sensitization with a central nervous system emulsion, there was little axonal pathology. Typical of mouse experimental allergic encephalomyelitis was the consistent involvement of polymorphonuclear leukocytes and extravasated material in central nervous system lesions. Remissions showed remyelination to be the major feature in the central nervous system, and clinical relapses were matched pathologically by fresh waves of inflammation and demyelination. Unusually large, apparently organized, sinusoidal collections of lymphoid cells (some of them displaying evidence of proliferation) were seen in the periventricular areas of the brain. The ability to induce chronic relapsing demyelination by passive means indicates that an antigen depot is not necessary for the perpetuation of the disease which is possibly transferred by memory cells in the inoculum. This model has virtue in its applicability to the pathogenesis and therapy of multiple sclerosis.
描述了一种新的慢性复发性实验性变应性脑脊髓炎模型的精细结构，该模型是通过单次过继转移髓鞘碱性蛋白致敏的淋巴结细胞在SJL/J小鼠中诱导产生的。该病症的神经病理学与其他物种中所见的情况相比具有优势，并且与通过用中枢神经系统乳剂主动致敏在同一品系小鼠中诱导的类似疾病不同，几乎没有轴索病理学改变。小鼠实验性变应性脑脊髓炎的典型特征是中枢神经系统病变中多形核白细胞和渗出物质的持续累及。缓解期显示中枢神经系统的主要特征是髓鞘再生，临床复发在病理上与新一波的炎症和脱髓鞘相匹配。在脑室周围区域可见异常大的、明显有组织的、窦状的淋巴细胞聚集（其中一些显示出增殖迹象）。通过被动方式诱导慢性复发性脱髓鞘的能力表明，抗原储存库对于疾病的持续存在不是必需的，疾病可能由接种物中的记忆细胞转移。该模型在适用于多发性硬化症的发病机制和治疗方面具有优点。
