Lublin F D
J Clin Lab Immunol. 1984 Apr;13(4):179-82.
Delayed, relapsing experimental allergic encephalomyelitis (DR-EAE) has been shown to be a good model of multiple sclerosis. This disorder has been produced in mice by immunization with whole central nervous system (CNS) tissue and adjuvants. The ability of various myelin components to produce DR-EAE was studied. Guinea pig myelin basic protein was able to induce DR-EAE that was clinically and pathologically identical to disease produced by whole CNS. Both acute inflammatory and chronic demyelinating lesions were seen in the CNS. Allogeneic mouse myelin basic protein either alone or in combination with cerebrosides and/or gangliosides was not able to produce DR-EAE.
迟发性复发性实验性变应性脑脊髓炎（DR-EAE）已被证明是多发性硬化症的良好模型。通过用全中枢神经系统（CNS）组织和佐剂免疫已在小鼠中诱发了这种疾病。研究了各种髓磷脂成分诱发DR-EAE的能力。豚鼠髓磷脂碱性蛋白能够诱发与全中枢神经系统诱发的疾病在临床和病理上相同的DR-EAE。在中枢神经系统中可见急性炎症性和慢性脱髓鞘性病变。同种异体小鼠髓磷脂碱性蛋白单独或与脑苷脂和/或神经节苷脂联合使用均不能诱发DR-EAE。
