Sowers J R
J Cardiovasc Pharmacol. 1984;6 Suppl 3:S477-82.
Through these actions on K+ balance, thiazide diuretics modify multiple endocrine systems. Potassium depletion likely contributes directly to disorders of carbohydrate metabolism, the renin-angiotensin-aldosterone axis, prostaglandin metabolism, and parathyroid hormone function. Besides these direct adverse effects on endocrine function, these disturbances likely contribute directly to the emergence of additional cardiovascular signs in subjects receiving long-term diuretic therapy.
通过对钾平衡的这些作用，噻嗪类利尿剂会改变多个内分泌系统。钾缺乏可能直接导致碳水化合物代谢紊乱、肾素 - 血管紧张素 - 醛固酮轴紊乱、前列腺素代谢紊乱以及甲状旁腺激素功能紊乱。除了这些对内分泌功能的直接不良影响外，这些紊乱可能直接导致接受长期利尿治疗的患者出现更多心血管症状。
