钙内流激活剂：二氢吡啶和氨基吡啶作用的不同位点。

Calcium entry activators: distinct sites of dihydropyridine and aminopyridine action.

作者信息

Greenberg D A, Cooper E C, Carpenter C L

出版信息

Neurosci Lett. 1984 Sep 7;50(1-3):279-82. doi: 10.1016/0304-3940(84)90499-3.

PMID:6208517

Abstract

The dihydropyridine compound BAY K 8644, a putative calcium entry activator, inhibits binding of the dihydropyridine calcium entry blocker, [3H]nitrendipine, to rat skeletal muscle membranes. In contrast, aminopyridine compounds also believed to stimulate calcium flux do not interact with [3H]nitrendipine binding sites in skeletal muscle or brain. These findings suggest that calcium entry activators, like calcium entry blockers, affect voltage-dependent calcium channels by diverse mechanisms.

摘要

二氢吡啶化合物BAY K 8644是一种假定的钙内流激活剂，它能抑制二氢吡啶类钙内流阻滞剂[3H]尼群地平与大鼠骨骼肌膜的结合。相比之下，同样被认为能刺激钙通量的氨基吡啶化合物却不与骨骼肌或大脑中的[3H]尼群地平结合位点相互作用。这些发现表明，钙内流激活剂与钙内流阻滞剂一样，通过多种机制影响电压依赖性钙通道。