Tremblay Y, Bélanger A, Labrie F, Frenette G, Dubé J Y, Tremblay R R
Prostate. 1984;5(6):631-8. doi: 10.1002/pros.2990050609.
Daily subcutaneous administration for 3 months of the potent LHRH agonist (D-Ser(TBU)6, des-Gly-NH2(10] LHRH ethylamide (25 micrograms) to adult dogs having spontaneous benign prostate hyperplasia (BPH) causes a marked inhibition of testicular androstenedione and testosterone secretion. This inhibition of delta 4-androgen secretion is accompanied by a decrease of testicular progestin precursors and 5 alpha-androgen metabolites, thus suggesting that, in dog, the loss of testicular steroidogenic activity, induced by the administration of an LHRH agonist, is due to a total inhibition of testicular steroidogenesis. In plasma, the concentration of both testosterone and dihydrotestosterone is also markedly depressed while androstane-3 alpha, 17 beta-diol levels remain unchanged. Measurement of prostatic steroid content has shown that administration of the LHRH agonist as well as castration is associated with a marked decrease in androstenedione, testosterone, and dihydrotestosterone levels in prostate while there is a small inhibition of androst-5-ene-3 beta, 17 beta-diol, androstane-3 beta, 17 beta-diol, dehydroepiandrosterone, and estrone concentrations in this tissue. The present data show that treatment with an LHRH agonist in the dog causes a marked inhibition of testicular steroid secretion similar to the one observed in adult men, and suggest that steroids from adrenal origin may also be involved in prostatic function.
对患有自发性良性前列腺增生（BPH）的成年犬每日皮下注射强效促黄体生成素释放激素（LHRH）激动剂（D-丝氨酸（叔丁基）6，去甘氨酸-NH2（10]LHRH乙酰胺，25微克），持续3个月，可显著抑制睾丸雄烯二酮和睾酮分泌。这种对δ4-雄激素分泌的抑制伴随着睾丸孕激素前体和5α-雄激素代谢产物的减少，因此表明，在犬中，LHRH激动剂给药诱导的睾丸类固醇生成活性丧失是由于睾丸类固醇生成的完全抑制。在血浆中，睾酮和双氢睾酮的浓度也显著降低，而雄烷-3α，17β-二醇水平保持不变。前列腺类固醇含量的测量表明，LHRH激动剂给药以及去势与前列腺中雄烯二酮、睾酮和双氢睾酮水平的显著降低有关，而该组织中雄甾-5-烯-3β，17β-二醇、雄烷-3β，17β-二醇、脱氢表雄酮和雌酮浓度有轻微抑制。目前的数据表明，在犬中用LHRH激动剂治疗会导致睾丸类固醇分泌的显著抑制，类似于在成年男性中观察到的情况，并表明来自肾上腺的类固醇也可能参与前列腺功能。
