von der Maase H, Engelholm S A, Rørth M, Sandberg Nielsen E, Schultz H P, Svennekjaer I L, Vaeth M
Acta Radiol Oncol. 1984;23(4):255-61. doi: 10.3109/02841868409136021.
Over a 5-year period (1976-1980) 499 patients with non-seminomatous testicular germ cell tumours were included in the Danish Testicular Carcinoma Study (DATECA). The 3-year crude survival for patients in clinical stages I, II and III was 91, 77 and 45 per cent, respectively. In stage I the relapse-free survival for patients given radiation combined with bleomycin and vincristine was significantly higher than that for patients given radiation alone. No difference in the crude survival was observed. For stage II patients maintenance chemotherapy following radiation combined with bleomycin and vincristine did not improve relapse-free or crude survival. The survival of patients with non-seminomatous tumours improved significantly during the 5-year period. This improvement was probably due to the introduction of cis-platinum in the treatment.
在1976年至1980年的5年期间,499例非精原细胞瘤性睾丸生殖细胞肿瘤患者被纳入丹麦睾丸癌研究(DATECA)。临床I期、II期和III期患者的3年粗生存率分别为91%、77%和45%。在I期,接受放疗联合博来霉素和长春新碱的患者无复发生存率显著高于单纯接受放疗的患者。粗生存率未见差异。对于II期患者,放疗联合博来霉素和长春新碱后进行维持化疗并未改善无复发生存率或粗生存率。在这5年期间,非精原细胞瘤患者的生存率显著提高。这种改善可能归因于治疗中引入了顺铂。