血清因子对IgE介导的全血组胺释放的影响。
Effect of a serum factor on IgE-mediated histamine release from whole blood.
作者信息
Tanizaki Y, Komagoe H, Sudo M, Morinaga H, Nakagawa S, Kitani H, Takahashi K, Kimura I
出版信息
Acta Med Okayama. 1984 Aug;38(4):381-7. doi: 10.18926/AMO/30315.
IgE-mediated histamine release from whole blood was analyzed in 44 patients with bronchial asthma by observing maximum present release and dose-response curves of histamine release induced by anti-IgE and house dust extract. The maximum histamine release from whole blood induced by anti-IgE correlated with total serum IgE levels. There was a close correlation between allergen-induced release from whole blood and the serum levels of specific IgE antibodies. In the maximum histamine release from whole blood induced by both anti-IgE and allergen, the interaction with a serum factor was not clearly recognized. Effect of a serum factor was shown in the dose-response curves of anti-IgE-induced histamine release, but not in those of allergen-induced histamine release. The dose-response curves caused by anti-IgE showed that basophils from cases with a high serum IgE level require much more anti-IgE to produce maximum histamine release than basophils from cases with a low serum IgE level. The results showed that IgE molecules contained in the serum participate in anti-IgE-induced histamine release from whole blood.
通过观察抗IgE和屋尘提取物诱导的组胺释放的最大现释和剂量反应曲线，分析了44例支气管哮喘患者全血中IgE介导的组胺释放。抗IgE诱导的全血中最大组胺释放与血清总IgE水平相关。全血中变应原诱导的释放与特异性IgE抗体的血清水平密切相关。在抗IgE和变应原诱导的全血中最大组胺释放中，未明确识别出与血清因子的相互作用。血清因子的作用在抗IgE诱导的组胺释放剂量反应曲线中显示，但在变应原诱导的组胺释放剂量反应曲线中未显示。抗IgE引起的剂量反应曲线表明，血清IgE水平高的病例的嗜碱性粒细胞比血清IgE水平低的病例的嗜碱性粒细胞需要更多的抗IgE才能产生最大组胺释放。结果表明，血清中含有的IgE分子参与抗IgE诱导的全血组胺释放。
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