Briese V, Willroth P O, Brock J, Straube W
Arch Geschwulstforsch. 1984;54(5):391-8.
Concentration of alpha 2-macroglobulin (AMG), pregnancy associated-alpha 2-glycoprotein (alpha 2-PAG, PZ) secretory immunoglobulin A (S-IgA), pregnancy specific-beta 1-glycoprotein (SP1) and immunoglobulin E (IgE) were estimated in serum samples of 88 patients with lung cancer of stages, II-IV. The proteins were determined by means of the single radial immunodiffusion and the rocket immunoelectrophoresis. AMG and S-IgA serum concentrations of the cancer group compared with those of the control group, were increased significantly. AMG (control group: means = 1,43 g/l; s = 0,999; tumor group: means = 4,37 g/l; s = 1,758); S-IgA (control group: means = 37 mg/l; s = 16,6; tumor group: means = 48 mg/l; s = 24,2). PZ was found only in 52% of the patients with lung cancer by means of the rocket immunoelectrophoresis. The difference between the tumour and the control group was not significant. IgE could be detected only in one case with lung cancer (IgE = 2950 IU/ml). It was not possible to detect SP1 by means of the single radial immunodiffusion in serum samples of lung cancer patients.
对88例II - IV期肺癌患者的血清样本进行了α2 - 巨球蛋白（AMG）、妊娠相关α2 - 糖蛋白（α2 - PAG，PZ）、分泌型免疫球蛋白A（S - IgA）、妊娠特异性β1 - 糖蛋白（SP1）和免疫球蛋白E（IgE）浓度的测定。这些蛋白质通过单向辐射免疫扩散和火箭免疫电泳法进行测定。与对照组相比，癌症组的AMG和S - IgA血清浓度显著升高。AMG（对照组：均值 = 1.43g/l；标准差 = 0.999；肿瘤组：均值 = 4.37g/l；标准差 = 1.758）；S - IgA（对照组：均值 = 37mg/l；标准差 = 16.6；肿瘤组：均值 = 48mg/l；标准差 = 24.2）。通过火箭免疫电泳法仅在52%的肺癌患者中检测到PZ。肿瘤组与对照组之间的差异不显著。仅在1例肺癌患者中检测到IgE（IgE = 2950IU/ml）。通过单向辐射免疫扩散法在肺癌患者血清样本中无法检测到SP1。
