Briese V, Strache R R, Büttner H H, Kunze M, Brock J, Röpcke G
Zentralbl Gynakol. 1987;109(5):265-73.
Concentrations of secretory immunoglobulin A (S-IgA), pregnancy associated alpha 2-glycoprotein (alpha 2-PAG) and circulating immune complexes (CIC) were estimated in serum samples of 20 blood donors, 14 patients with benign mamma tumors, 44 patients with mastopathies and 33 patients with breast cancer disease. The proteins were determined by means of the single radial immunodiffusion and the polyethylene glycol precipitation. S-IgA serum concentrations of the cancer group compared with those of the benign tumors, were increased significantly (benign tumors: mean = 40.27 mg/l; s = 15.61; carcinoma disease: mean = 78.87 mg/l; s = 72.80). alpha 2-PAG serum concentrations of the cancer-and benign tumor group as well as the mastopathy group were also increased significantly in comparison with the blood donor group (blood donors: mean = 143.75 mg/l; s = 198.50; benign tumors: mean = 295.85 mg/l; s = 232.64; mastopathies: mean = 190.86 mg/l; s = 177.77; carcinoma disease: mean = 192.52 mg/l; s = 172.88).
对20名献血者、14名患有良性乳腺肿瘤的患者、44名患有乳腺病的患者以及33名患有乳腺癌的患者的血清样本，测定了分泌型免疫球蛋白A（S-IgA）、妊娠相关α2-糖蛋白（α2-PAG）和循环免疫复合物（CIC）的浓度。这些蛋白质通过单向放射免疫扩散法和聚乙二醇沉淀法进行测定。与良性肿瘤组相比，癌症组的S-IgA血清浓度显著升高（良性肿瘤组：均值 = 40.27 mg/l；标准差 = 15.61；癌症组：均值 = 78.87 mg/l；标准差 = 72.80）。与献血者组相比，癌症组、良性肿瘤组以及乳腺病组的α2-PAG血清浓度也显著升高（献血者组：均值 = 143.75 mg/l；标准差 = 198.50；良性肿瘤组：均值 = 295.85 mg/l；标准差 = 232.64；乳腺病组：均值 = 190.86 mg/l；标准差 = 177.77；癌症组：均值 = 192.52 mg/l；标准差 = 172.88）。
