Hall J B, Wadham B M, Wood C J, Ashton V, Adam W R
Aust N Z J Med. 1984 Jun;14(3):277-8. doi: 10.1111/j.1445-5994.1984.tb03769.x.
Four subjects whose plasma produced positive staining of neutrophil cytoplasm, on testing for antinuclear factor, have been found over eight years (and over 10,000 antinuclear factor studies). All four had evidence of diffuse systemic disease with polyarthralgia and lung involvement. Three of four (at least) had evidence of renal involvement and two of four skin biopsy evidence of vasculitis. Defining such a subgroup may help in defining etiology(s) and treatment regimes in diffuse vasculitic disease.
在八年时间里（以及超过10000次抗核因子检测中），发现有四名受试者的血浆在检测抗核因子时，出现中性粒细胞胞浆阳性染色。这四名受试者均有弥漫性全身性疾病的证据，伴有多关节痛和肺部受累。四名受试者中有三名（至少）有肾脏受累的证据，四名中有两名有皮肤活检显示血管炎的证据。定义这样一个亚组可能有助于明确弥漫性血管炎性疾病的病因和治疗方案。
