Bovin N V, Khorlin A Ia
Bioorg Khim. 1984 Jun;10(6):853-60.
Synthesis of blood group ABH (type 1) determinant oligosaccharides and Leb tetrasaccharide has been performed using the same trisaccharide precursor-benzyl 2-acetamido-4,6-O-benzylidene-[4,6-O-benzylidene-2-O-[2-O-benzyl-3,4-di- O- (4-nitrobenzoyl)-alpha-L-fucopyranosyl]-beta-D-galactopyranosyl]-2-deoxy - alpha-D-glucopyranoside. A- and B-determinants were prepared by alpha-galactosaminylation and alpha-galactosylation of the title trisaccharide, respectively. Leb-determinant was synthesized by a series of simple blocking and deblocking steps followed by alpha-fucosylation.
已使用相同的三糖前体——苄基 2-乙酰氨基-4,6-O-亚苄基-[4,6-O-亚苄基-2-O-[2-O-苄基-3,4-二-O-(4-硝基苯甲酰基)-α-L-岩藻糖基吡喃糖基]-β-D-半乳糖吡喃糖基]-2-脱氧-α-D-葡萄糖苷，进行了血型 ABH（1 型）决定簇寡糖和 Leb 四糖的合成。A 决定簇和 B 决定簇分别通过标题三糖的α-氨基半乳糖基化和α-半乳糖基化制备。Leb 决定簇通过一系列简单的封闭和去封闭步骤，随后进行α-岩藻糖基化来合成。
