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[诱导性半乳糖血症期间排泄的尿寡糖的结构和免疫化学性质]

[Structure and immunochemical properties of the urinary oligosaccharides excreted during induced galactosuria].

作者信息

Strecker G, Riazi-Farzad T, Fournet B, Bouquelet S, Montreuil J

出版信息

Biochimie. 1976;58(7):815-25. doi: 10.1016/s0300-9084(76)80312-4.

DOI:10.1016/s0300-9084(76)80312-4
PMID:61769
Abstract

Induced galactosuria is characterized by the excretion in urine of large amounts of new oligosaccharides, the structure of which are in connection with blood-group phenotypes ABH, Lewis and Secretor: O group : O-alpha-L fucopyranosyl-(1 leads to 2)-D galactopyranose et O-alpha-L fucopyranosyl-(1 leads to 2)-O-beta-D galactopyranosyl-(1 leads to 3)-[O-alpha-L fucopyranosyl-(1 leads to 4)]-O-beta-D 2-deoxy-2 acetamido-glucopyranosyl-(1 leads to 4)-[O-alpha-L fucopyranosyl-(1 leads to 6)]-D-galactopyranose. A group: O-alpha-D-2-deoxy-2 acetamido-galactopyranosyl-(1 leads to 3)-[O-alpha-L fucopyranosyl-(1 leads to 2)]-D galactopyranose et O-alpha-D-2-deoxy-2 acetamido-galactopyranosyl-(1 leads to 3)-[O-alpha-L fucopyranosyl-(1 leads to 2)]-O-beta-D galactopyranosyl-(1 leads to 3)-[O-alpha-L fucopyranosyl-(1 leads to 4)]-O-beta-D-2-deoxy-2 acetamido-glucopyranosyl-(1 leads to)-[O-alpha-L fucopyranosyl-(1 leads to 6)]-D galactopyranose. B group : O-alpha-D galactopyranosyl-(1 leads to 3)-[O-alpha-L fucopyranosyl-(1 leads to 2)]-D galactopyranose et O-alpha-D galactopyranosyl-(1 leads to 3)-[O-alpha-L fucopyranosyl-(1 leads to 2)]-O-beta-D galactopyranosyl-(1 leads to 3)-[O-alpha-L fucopyranosyl-(1 leads to 4)]-O-beta-D-2-deoxy-2 acetamido-glucopyranosyl-(1 leads to 4)-[O-alpha-L fucopyranosyl-(1 leads to 6)]-D-galactopyranose.

摘要

诱发性半乳糖尿症的特征是尿液中排泄大量新的寡糖，其结构与ABH、Lewis血型表型和分泌型相关：O型：O-α-L-呋喃岩藻糖基-(1→2)-D-吡喃半乳糖以及O-α-L-呋喃岩藻糖基-(1→2)-O-β-D-吡喃半乳糖基-(1→3)-[O-α-L-呋喃岩藻糖基-(1→4)]-O-β-D-2-脱氧-2-乙酰氨基-吡喃葡萄糖基-(1→4)-[O-α-L-呋喃岩藻糖基-(1→6)]-D-吡喃半乳糖。A型：O-α-D-2-脱氧-2-乙酰氨基-吡喃半乳糖基-(1→3)-[O-α-L-呋喃岩藻糖基-(1→2)]-D-吡喃半乳糖以及O-α-D-2-脱氧-2-乙酰氨基-吡喃半乳糖基-(1→3)-[O-α-L-呋喃岩藻糖基-(1→2)]-O-β-D-吡喃半乳糖基-(1→3)-[O-α-L-呋喃岩藻糖基-(1→4)]-O-β-D-2-脱氧-2-乙酰氨基-吡喃葡萄糖基-(1→)-[O-α-L-呋喃岩藻糖基-(1→6)]-D-吡喃半乳糖。B型：O-α-D-吡喃半乳糖基-(1→3)-[O-α-L-呋喃岩藻糖基-(1→2)]-D-吡喃半乳糖以及O-α-D-吡喃半乳糖基-(1→3)-[O-α-L-呋喃岩藻糖基-(1→2)]-O-β-D-吡喃半乳糖基-(1→3)-[O-α-L-呋喃岩藻糖基-(1→4)]-O-β-D-2-脱氧-2-乙酰氨基-吡喃葡萄糖基-(1→4)-[O-α-L-呋喃岩藻糖基-(1→6)]-D-吡喃半乳糖。

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