Zaletok S P, Berdinskikh N K, Draga N V
Eksp Onkol. 1984;6(4):10-7.
The data on location of polyamines (spermine, spermidine, putrescine) in cells of different tissues and organs, intracellular polyamines distribution and the factors controlling polyamine metabolism are reviewed. Certain aspects of a regulatory role of polyamines in nucleic acid and protein synthesis and of changes in the activity of the enzymes participating in the synthesis and degradation of polyamines in the neoplastic growth are dealth with. The data available in literature and the results of the authors own investigations concerning the use of the polyamine test for diagnosis and evaluation of malignant tumours treatment efficiency are presented.
本文综述了多胺（精胺、亚精胺、腐胺）在不同组织和器官细胞中的定位数据、细胞内多胺分布以及控制多胺代谢的因素。探讨了多胺在核酸和蛋白质合成中的调节作用以及参与肿瘤生长过程中多胺合成与降解的酶活性变化的某些方面。介绍了文献中可用的数据以及作者自己关于使用多胺检测诊断和评估恶性肿瘤治疗效果的研究结果。
