Zhang S Q, Terenghi G, Unger W G, Ennis K W, Polak J
Exp Eye Res. 1984 Sep;39(3):365-72. doi: 10.1016/0014-4835(84)90024-1.
Substance P (SP)-immunoreactive fibres have been found in the rat and guinea-pig irides. They are distributed parallel to the pupillary margin in the sphincter muscle, and in an irregular plexus in the dilator muscle of both species. Neuropeptide Y (NPY)-immunoreactive fibres have also been demonstrated in the anterior uvea, displaying a pattern similar to that of the adrenergic nerves. One month after sympathectomy, there was an increase both in the density and possibly in the number of SP-immunoreactive fibres in the denervated irides of both rodent species. In the sympathectomized iris, there was a very notable decrease in the density of NPY-immunoreactive fibres indicating that the NPY peptide most likely coexists with the classical sympathetic neurotransmitter, noradrenaline, in the sympathetic nerve supply derived from the superior cervical ganglion. The disappearance of dopamine beta-hydroxylase (DBH) immunostaining fibres confirmed the success of the sympathetic denervation.
在大鼠和豚鼠的虹膜中发现了P物质（SP）免疫反应性纤维。它们在括约肌中与瞳孔边缘平行分布，在两种动物的瞳孔开大肌中呈不规则的神经丛分布。神经肽Y（NPY）免疫反应性纤维也在前葡萄膜中得到证实，其分布模式与肾上腺素能神经相似。交感神经切除术后一个月，两种啮齿动物去神经支配的虹膜中SP免疫反应性纤维的密度增加，数量可能也增加。在交感神经切除的虹膜中，NPY免疫反应性纤维的密度显著降低，这表明NPY肽很可能与经典的交感神经递质去甲肾上腺素在来自颈上神经节的交感神经供应中共存。多巴胺β-羟化酶（DBH）免疫染色纤维的消失证实了交感神经去神经支配的成功。
