豚鼠血管周围神经纤维中的神经肽Y样免疫反应性

Neuropeptide Y-like immunoreactivity in perivascular nerve fibres of the guinea-pig.

作者信息

Uddman R, Ekblad E, Edvinsson L, Håkanson R, Sundler F

出版信息

Regul Pept. 1985 Mar;10(2-3):243-57. doi: 10.1016/0167-0115(85)90019-9.

Abstract

The distribution of perivascular nerve fibres displaying neuropeptide Y-like immunoreactivity was studied in the guinea-pig. Generally, neuropeptide Y fibres were numerous around arteries and moderate in number around veins. In the heart, immunoreactive fibres were numerous in the auricles and the atria (epi- and endocardium) whereas the ventricles had a more scarce supply. The coronary vessels were richly supplied with fibres. Around large elastic and muscular arteries the fibres formed well developed plexuses. Small arteries in the respiratory tract, the gastrointestinal tract and the genito-urinary tract received a particularly rich supply. In the liver, spleen and kidney only few perivascular fibres were seen. Since immunoreactive fibres around blood vessels disappeared upon surgical or chemical sympathectomy, and sequential immunostaining with antisera against dopamine-beta-hydroxylase (a marker for adrenergic neurons) and against neuropeptide Y revealed their co-existence, it is concluded that neuropeptide Y fibres around blood vessels are sympathetic and adrenergic.

摘要

对豚鼠体内显示神经肽Y样免疫反应性的血管周围神经纤维分布进行了研究。一般来说，动脉周围的神经肽Y纤维数量众多，静脉周围的数量适中。在心脏中，免疫反应性纤维在耳廓和心房（心外膜和心内膜）中数量众多，而心室的供应则较为稀少。冠状血管有丰富的纤维供应。在大的弹性动脉和肌性动脉周围，纤维形成了发育良好的神经丛。呼吸道、胃肠道和泌尿生殖道的小动脉有特别丰富的供应。在肝脏、脾脏和肾脏中，仅可见少数血管周围纤维。由于手术或化学性交感神经切除后血管周围的免疫反应性纤维消失，并且用抗多巴胺-β-羟化酶（肾上腺素能神经元的标志物）和抗神经肽Y的抗血清进行连续免疫染色显示它们共存，因此得出结论，血管周围的神经肽Y纤维是交感神经和肾上腺素能的。