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大鼠最后区中单胺和肽的超微结构定位

Ultrastructural localization of monoamines and peptides in rat area postrema.

作者信息

Pickel V M, Armstrong D M

出版信息

Fed Proc. 1984 Dec;43(15):2949-51.

PMID:6209170
Abstract

An overall schema for the synaptic interactions of monoaminergic and peptidergic neurons and their relation to the ventricle and to blood vessels within the rat area postrema is presented. The specific markers include: 1) the immunocytochemical localization of the catecholamine-synthesizing enzyme tyrosine hydroxylase, and the neuropeptides enkephalin and substance P; and 2) the radioautographic localization of [3H]serotonin (5-hydroxytryptamine) and 3H-labeled amino acids anterogradely transported from the nodose ganglion.

摘要

本文展示了大鼠最后区单胺能和肽能神经元突触相互作用的整体模式,以及它们与脑室和血管的关系。具体标记物包括:1)儿茶酚胺合成酶酪氨酸羟化酶、脑啡肽和P物质的免疫细胞化学定位;2)[3H]血清素(5-羟色胺)和从结状神经节顺行转运的3H标记氨基酸的放射自显影定位。

相似文献

1
Ultrastructural localization of monoamines and peptides in rat area postrema.大鼠最后区中单胺和肽的超微结构定位
Fed Proc. 1984 Dec;43(15):2949-51.
2
Immunocytochemical localization of catecholamine synthesizing enzymes and neuropeptides in area postrema and medial nucleus tractus solitarius of rat brain.大鼠脑最后区和孤束核中儿茶酚胺合成酶和神经肽的免疫细胞化学定位
J Comp Neurol. 1981 Mar 1;196(3):505-17. doi: 10.1002/cne.901960312.
3
Electron microscopic immunocytochemical localization of tyrosine hydroxylase in the area postrema of rat.大鼠最后区酪氨酸羟化酶的电子显微镜免疫细胞化学定位
J Comp Neurol. 1982 Apr 10;206(3):259-72. doi: 10.1002/cne.902060306.
4
Tyrosine hydroxylase and enkephalin in nuclei of the solitary tracts: co-existence and convergent synaptic input to catecholamine neurons.孤束核中的酪氨酸羟化酶和脑啡肽:共存以及对儿茶酚胺能神经元的汇聚性突触输入。
Prog Clin Biol Res. 1990;328:267-70.
5
Distribution of enkephalin, substance P, tyrosine hydroxylase, and 5-hydroxytryptamine immunoreactivity in the septal region of the rat.脑啡肽、P物质、酪氨酸羟化酶和5-羟色胺免疫反应性在大鼠隔区的分布
J Comp Neurol. 1984 May 10;225(2):212-27. doi: 10.1002/cne.902250207.
6
Localization of tyrosine hydroxylase in neuronal targets and efferents of the area postrema in the nucleus tractus solitarii of the rat.大鼠孤束核中最后区神经元靶点及传出纤维中酪氨酸羟化酶的定位
J Comp Neurol. 1993 Mar 15;329(3):337-53. doi: 10.1002/cne.903290305.
7
Serotoninergic terminals: ultrastructure and synaptic interaction with catecholamine-containing neurons in the medial nuclei of the solitary tracts.
J Comp Neurol. 1984 May 10;225(2):291-301. doi: 10.1002/cne.902250212.
8
Immunocytochemical localization of neuronal antigens: tyrosine hydroxylase, substance P, [Met5]-enkephalin.
Fed Proc. 1979 Sep;38(10):2374-80.
9
Enkephalin-like immunoreactivity in rat area postrema: ultrastructural localization and coexistence with serotonin.
Brain Res. 1984 Sep 24;310(2):269-78. doi: 10.1016/0006-8993(84)90150-1.
10
Dual immunostaining procedure demonstrating neurotransmitter and neuropeptide codistribution in the same brain section.双重免疫染色程序显示同一脑切片中神经递质和神经肽的共分布。
Am J Anat. 1986 Feb-Mar;175(2-3):331-42, 356-61. doi: 10.1002/aja.1001750215.

引用本文的文献

1
A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research.治疗恶心和呕吐的药物发现史及其对未来研究的启示
Front Pharmacol. 2018 Sep 4;9:913. doi: 10.3389/fphar.2018.00913. eCollection 2018.
2
Pharmacological Agents Affecting Emesis : A Review (Part II).影响呕吐的药物制剂:综述(第二部分)
Drugs. 1992 Apr;43(4):443-463. doi: 10.2165/00003495-199243040-00003.
3
Distribution of alpha 2-adrenergic binding sites in the parabrachial complex of the rat.大鼠臂旁复合体中α2-肾上腺素能结合位点的分布
Anat Embryol (Berl). 1995 Dec;192(6):507-16. doi: 10.1007/BF00187181.
4
Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism.选择性5-羟色胺M受体拮抗作用对顺铂所致呕吐的抑制作用
Br J Pharmacol. 1986 Jul;88(3):497-9. doi: 10.1111/j.1476-5381.1986.tb10228.x.
5
Chemotherapy induced emesis--mechanisms and treatment: a review.化疗引起的呕吐——机制与治疗:综述
J R Soc Med. 1988 Nov;81(11):658-62. doi: 10.1177/014107688808101115.
6
5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret.将5-羟色胺3受体拮抗剂注入最后区可抑制雪貂顺铂诱导的呕吐。
Br J Pharmacol. 1989 May;97(1):247-55. doi: 10.1111/j.1476-5381.1989.tb11948.x.