Göke B, Stöckmann F, Müller R, Lankisch P G, Creutzfeldt W
Digestion. 1984;30(3):171-8. doi: 10.1159/000199102.
Camostate, a synthetic serine protease inhibitor, specifically inhibits the trypsin activity in vitro. Immediately after intravenous administration of camostate (5, 2.5, 0.5, and 0.1 mg/kg body weight/h) the trypsin activity in the biliary-pancreatic juice was diminished dose-dependently in anaesthetized rats. The amylase release was not influenced. Camostate and its metabolites were detected by high-pressure liquid chromatography in the pancreatic juice and tissue; in plasma, only the metabolites were found. Therefore, the inhibitory action of camostate on the trypsin activity in the biliary-pancreatic juice may be due to penetration of camostate into the juice.
卡莫司他是一种合成的丝氨酸蛋白酶抑制剂，在体外能特异性抑制胰蛋白酶活性。在麻醉大鼠中静脉注射卡莫司他（5、2.5、0.5和0.1毫克/千克体重/小时）后，胆汁胰液中的胰蛋白酶活性立即呈剂量依赖性降低。淀粉酶释放未受影响。通过高压液相色谱法在胰液和组织中检测到了卡莫司他及其代谢产物；在血浆中，仅发现了代谢产物。因此，卡莫司他对胆汁胰液中胰蛋白酶活性的抑制作用可能是由于卡莫司他渗透到了胰液中。
