Strejan G H, Gilbert J J, St Louis J
J Neuroimmunol. 1984 Nov;7(1):27-41. doi: 10.1016/s0165-5728(84)80004-1.
Juvenile strain-13 guinea pigs were challenged with isologous spinal cord in CFA. After recovery from the first EAE episode the animals were treated with guinea pig MBP inserted into liposomes, with cytochrome-c-liposomes, with MBP in saline or with MBP in IFA. Guinea pigs treated with MBP-liposomes showed a striking reduction in clinical signs and in the number and intensity of relapses. They displayed virtually no demyelinating lesions, and had comparatively little parenchymal inflammation in the spinal cord. Early T rosette levels showed an inverse correlation with the severity of histological lesions in the spinal cord but correlation with the clinical status at the time of rosette assay was less well defined.
将幼年13号品系豚鼠用完全弗氏佐剂中的同源脊髓进行攻击。在首次实验性自身免疫性脑脊髓炎发作恢复后，用插入脂质体的豚鼠髓鞘碱性蛋白、细胞色素c脂质体、盐水中的髓鞘碱性蛋白或不完全弗氏佐剂中的髓鞘碱性蛋白对动物进行治疗。用髓鞘碱性蛋白脂质体治疗的豚鼠临床症状、复发次数和强度均显著降低。它们几乎没有脱髓鞘病变，脊髓实质炎症也相对较少。早期T玫瑰花结水平与脊髓组织学损伤的严重程度呈负相关，但与玫瑰花结试验时的临床状态相关性不太明确。
