McDermott J R, Keith A B
Eur Neurol. 1979;18(2):136-9. doi: 10.1159/000115068.
Isolated myelin basic protein (MBP) was less effective than an equivalent amount of spinal cord in inducing protection against experimental allergic encephalomyelitis produced by a challenge of either cord, purified myelin or MBP. Complete protection was only obtained when an MBP challenge was preceded by spinal cord treatment. There was a 100% incidence of disease in the guinea pigs pretreated with MBP before challenge with spinal cord or myelin, but the onset was delayed by 3--4 weeks and the disease was less severe than in the controls. Recurrent disease was seen in some control and pretreated animals challenged with spinal cord but not in animals challenged with MBP.
分离出的髓鞘碱性蛋白（MBP）在诱导针对由脊髓、纯化髓鞘或 MBP 激发所产生的实验性变应性脑脊髓炎的保护作用方面，不如等量的脊髓有效。只有在脊髓处理先于 MBP 激发时才能获得完全保护。在用脊髓或髓鞘激发之前先用 MBP 预处理的豚鼠中，疾病发生率为 100%，但发病延迟 3 - 4 周，且疾病严重程度低于对照组。在用脊髓激发的一些对照动物和预处理动物中出现了复发性疾病，但在用 MBP 激发的动物中未出现。
