Yagi Y, Saku T, Hatae M, Yagi S, Fujisaki H, Shimotsu T
Gan No Rinsho. 1984 Sep;30(11):1392-7.
Immunoperoxidase staining for human keratin proteins (hKP) was performed cytochemically in samples from 79 cancer patients, and histochemically in samples from 134 cancer patients. Immunohistochemically, hKP was present in almost all patients with squamous cell carcinoma (lung), transitional cell carcinoma (urinary bladder), adenocarcinoma (lung, stomach, breast, ovary), bronchiole-alveolar carcinoma (lung), and large cell carcinoma (lung). It was detected in 40% of the patients with small cell carcinoma (lung). Histochemically, hKP was present in patients with squamous cell carcinoma (lung, uterine body), adenocarcinoma (lung, stomach, colon, gall bladder, thyroid, uterine body), adenosquamous cell carcinoma (gall bladder, uterine body), Signet-ring cell carcinoma (stomach), clear cell carcinoma (uterine body) and undifferentiated carcinoma (uterine body). However, it was not detected in patients with brochiole ++-alveola ++ carcinoma (lung) and mucinous carcinoma (gall bladder).
对79例癌症患者的样本进行了人角蛋白（hKP）的免疫过氧化物酶细胞化学染色，并对134例癌症患者的样本进行了组织化学染色。免疫组织化学显示，hKP几乎存在于所有鳞状细胞癌（肺）、移行细胞癌（膀胱）、腺癌（肺、胃、乳腺、卵巢）、细支气管肺泡癌（肺）和大细胞癌（肺）患者中。在40%的小细胞癌（肺）患者中检测到hKP。组织化学显示，hKP存在于鳞状细胞癌（肺、子宫体）、腺癌（肺、胃、结肠、胆囊、甲状腺、子宫体）、腺鳞癌（胆囊、子宫体）、印戒细胞癌（胃）、透明细胞癌（子宫体）和未分化癌（子宫体）患者中。然而，在细支气管++ -肺泡++癌（肺）和黏液腺癌（胆囊）患者中未检测到hKP。
