Gosseye S, Fox H
Placenta. 1984 Jul-Aug;5(4):329-47. doi: 10.1016/s0143-4004(84)80014-4.
Using an immunoperoxidase technique the localization of hCG, hPL, SP1, PAPP-A and PP5 within villous and extravillous trophoblast has been studied. The villous syncytiotrophoblast appears to be the sole significant source of hCG, SP1, PAPP-A and PP5 but hPL is also present in the infiltrating extravillous trophoblast. Within the interstitial extravillous trophoblast the proportion of cells staining positively for hPL increases progressively as the cells extend deeper into the uterine tissues but all the vascular extravillous trophoblast within the lumina of the spiral arteries stains positively for hPL at all levels within the decidua and inner myometrium. It is not clear why the synthetic capacity of the infiltrating trophoblast is limited to the production of hPL. We suggest that this might be indicative of selectivity of a specific subpopulation of cytotrophoblastic cells. It is unlikely that the physiological effects of infiltrating trophoblast are mediated by hPL, this substance being probably only a marker of a cell population with a particular invasive capacity.
采用免疫过氧化物酶技术，研究了人绒毛膜促性腺激素（hCG）、人胎盘催乳素（hPL）、妊娠相关血浆蛋白A（PAPP - A）和胎盘磷酸酯酶5（PP5）在绒毛和绒毛外滋养层中的定位。绒毛合体滋养层似乎是hCG、SP1、PAPP - A和PP5的唯一重要来源，但hPL也存在于浸润性绒毛外滋养层中。在间质绒毛外滋养层中，随着细胞向子宫组织深部延伸，hPL染色阳性的细胞比例逐渐增加，但螺旋动脉管腔内的所有血管绒毛外滋养层在蜕膜和子宫肌层内的各个层面hPL染色均为阳性。目前尚不清楚浸润性滋养层的合成能力为何仅限于hPL的产生。我们认为，这可能表明细胞滋养层细胞的特定亚群具有选择性。浸润性滋养层的生理作用不太可能由hPL介导，这种物质可能只是具有特定侵袭能力的细胞群体的一个标志物。
