Reuther K, Aagaard J
Urol Int. 1984;39(5):312-3. doi: 10.1159/000281000.
Detrusor instability secondary to infravesical obstruction is probably caused by overactive stretch receptors in the bladder wall. Since recent studies have shown that alpha-adrenergic blockade with phenoxybenzamine reduces the intravesical pressure under micturition, we undertook this investigation in order to see if phenoxybenzamine has an effect on detrusor instability caused by infravesical obstruction. We found that the detrusor instability was abolished by phenoxybenzamine, which supports the 'stretch receptor theory'. Further, phenoxybenzamine is probably a good test in the diagnosis of detrusor instability secondary to infravesical obstruction.
膀胱颈以下梗阻继发的逼尿肌不稳定可能是由膀胱壁内过度活跃的牵张感受器引起的。由于最近的研究表明，用酚苄明进行α-肾上腺素能阻滞可降低排尿时的膀胱内压，我们进行了这项研究，以观察酚苄明对膀胱颈以下梗阻所致逼尿肌不稳定是否有影响。我们发现酚苄明可消除逼尿肌不稳定，这支持了“牵张感受器理论”。此外，酚苄明可能是诊断膀胱颈以下梗阻继发逼尿肌不稳定的一种很好的检测方法。
