Droller M J
Urol Clin North Am. 1984 Nov;11(4):643-57.
The putative role of the immune response in the natural defense against neoplasia remains poorly defined. Correspondingly, its potential recruitment as a means of cancer therapy has remained unfulfilled. The intricate interactions of immune response mechanisms as well as the heterogeneity of tumor cells themselves have contributed to this situation. Moreover, the immunosenescence that occurs during aging may have further compromised potential means of recruiting immune response mechanisms in treating cancer. The various attempts to treat different types of genitourinary neoplasia are illustrations of these difficulties, and emphasize directions that may need attention in future therapeutic efforts.
免疫反应在肿瘤天然防御中的假定作用仍未明确界定。相应地，将其作为癌症治疗手段的潜在应用尚未实现。免疫反应机制的复杂相互作用以及肿瘤细胞本身的异质性导致了这种情况。此外，衰老过程中发生的免疫衰老可能进一步削弱了在癌症治疗中利用免疫反应机制的潜在手段。治疗不同类型泌尿生殖系统肿瘤的各种尝试体现了这些困难，并强调了未来治疗努力中可能需要关注的方向。
