Szymanski I O, Teno R A, Gandhi J G, Newburger P E
Vox Sang. 1984;47(5):325-9. doi: 10.1111/j.1423-0410.1984.tb04134.x.
We studied the rate of in vivo elimination of hydroxyethyl starch (HES) given during low dose HES leukapheresis in 9 donors and the effect of this procedure on the in vitro function of granulocytes in 3 donors. HES was eliminated more rapidly than has been previously reported for standard leukapheresis. Serum HES declined to one-half of peak concentration between 1 and 2 days and to one-tenth of peak in 23 days. No HES could be detected in serum 90 days after leukapheresis. The function of the harvested granulocytes was compared to that of granulocytes collected just prior to the procedure by measuring superoxide generation, ingestion and cell motility. There was no significant difference in the function of granulocytes harvested by low dose HES leukapheresis compared to those collected by venipuncture before the procedure.
我们研究了9名供者在低剂量羟乙基淀粉（HES）白细胞单采过程中给予的HES在体内的清除率，以及该过程对3名供者粒细胞体外功能的影响。HES的清除速度比先前报道的标准白细胞单采更快。血清HES在1至2天内降至峰值浓度的一半，在23天内降至峰值的十分之一。白细胞单采90天后血清中未检测到HES。通过测量超氧化物生成、吞噬作用和细胞运动性，将采集的粒细胞功能与该过程前采集的粒细胞功能进行比较。与静脉穿刺采集的粒细胞相比，低剂量HES白细胞单采采集的粒细胞功能无显著差异。
