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放线菌素-D对小鼠下丘脑特定核团神经细胞胞质RNA昼夜节律的影响。

Influence of actinomycin-D on the diurnal rhythm of cytoplasmic RNA in the neurocytes of selected nuclei of mouse hypothalamus.

作者信息

Lach H, Dziubek K, Krawczyk S, Szaroma W

出版信息

Acta Biol Hung. 1984;35(1):3-9.

PMID:6209875
Abstract

The influence of a single dose of actinomycin-D (1 mg/kg body weight) on the diurnal rhythm of cytoplasmic RNA was studied in neurocytes of the supraoptic nucleus (SON), paraventricular nucleus (PVN), and arcuate nucleus (AN) by microspectrophotometer. Cosinor analysis of the obtained results revealed a disturbed diurnal rhythm of cytoplasmic RNA in the animals treated with actinomycin-D. The mean diurnal RNA content in the SON, PVN, and AN neurocytes decreased, the amplitude of diurnal fluctuation was reduced and the acrophase was shifted to earlier hours.

摘要

采用显微分光光度计研究了单次剂量放线菌素-D（1毫克/千克体重）对视上核（SON）、室旁核（PVN）和弓状核（AN）神经细胞胞质RNA昼夜节律的影响。对所得结果进行余弦分析显示，经放线菌素-D处理的动物胞质RNA昼夜节律紊乱。SON、PVN和AN神经细胞的平均每日RNA含量降低，昼夜波动幅度减小，峰值相位提前。

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