朗格汉斯细胞与白癜风：表达T6和HLA-DR抗原细胞的定量研究。
Langerhans' cell and vitiligo: quantitative study of T6 and HLA-DR antigen-expressing cells.
作者信息
Claudy A L, Rouchouse B
出版信息
Acta Derm Venereol. 1984;64(4):334-6.
Epidermal Langerhans' cell (LC) densities in vitiliginous skin (VS) and normal-appearing skin (NAS) were studied in 10 patients with common vitiligo. Monoclonal mouse anti human T6 antigen IgG1 and Ia antigen IgG2 (Ortho Pharmaceuticals) were used to characterize LC. Epidermal LC densities were calculated by means of an ocular square grid and expressed per 0.1 mm2. The results showed that LC densities of VS was similar to that of NAS (p: not significant). No differences were noted in terms of age, sex, progressing, stable or repigmenting vitiligo. We concluded that involvement of LC in vitiligo, if any, does not probably occur via a degenerating mechanism, or via variations in regional densities.
对10例寻常型白癜风患者的白癜风皮肤（VS）和外观正常皮肤（NAS）中的表皮朗格汉斯细胞（LC）密度进行了研究。使用单克隆小鼠抗人T6抗原IgG1和Ia抗原IgG2（奥索制药公司）对LC进行鉴定。通过目镜方格网计算表皮LC密度，并以每0.1mm²表示。结果显示，VS的LC密度与NAS的相似（p：无显著性差异）。在年龄、性别、进展期、稳定期或复色期白癜风方面未发现差异。我们得出结论，LC在白癜风中的参与（如果有的话）可能不是通过退化机制或区域密度变化发生的。
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