Leport C, Janowski M, Brun-Vezinet F, Rouzioux C, Rodhain F, Vilde J L
Ann Med Interne (Paris). 1984;135(6):460-3.
A 68 year-old woman contracted West Nile fever after a stay of one month in Israel. Mild encephalitis and severe myelitis, resembling the "polio syndrome", developed, with important sequelae. Specific antibodies against West Nile fever virus progressively increased in the patient's serum. Epidemiological and clinical data about neurologic aspects of this infection are reviewed. Meningoencephalitis is not unusual, but only one previous case of acute anterior myelitis has been described in humans although this pathology is well known in experimental and veterinary diseases. Very few studies concern interferon and arbovirus infections in humans. Interferon assays in our patient's serum and cerebrospinal fluid showed its presence and persistence: this is in relation with the replication of the virus in the central nervous system, as it has been demonstrated in other primary viral encephalitis.
一名68岁女性在以色列停留一个月后感染了西尼罗河热。出现了轻度脑炎和严重脊髓炎，类似“小儿麻痹症综合征”，并伴有严重后遗症。患者血清中针对西尼罗河热病毒的特异性抗体逐渐增加。本文回顾了关于这种感染神经学方面的流行病学和临床数据。脑膜脑炎并不罕见，但此前仅在人类中描述过一例急性前脊髓炎病例，尽管这种病理情况在实验性疾病和兽医疾病中很常见。很少有研究涉及人类干扰素与虫媒病毒感染。对我们患者血清和脑脊液中的干扰素检测显示其存在且持续存在：这与病毒在中枢神经系统中的复制有关，正如在其他原发性病毒性脑炎中所证实的那样。
