向大鼠脑室内注射来自一名先天性无痛觉患者的脑脊液可诱导镇痛作用。
Intracerebroventricular injection of cerebrospinal fluid (CSF) from a patient with congenital indifference to pain induces analgesia in rats.
作者信息
Fabbri A, Fraioli F, Cruccu G, Manfredi M, Pert C B, Pert A
出版信息
Experientia. 1984 Dec 15;40(12):1365-6. doi: 10.1007/BF01951891.
PMID:6210210
Abstract
CSF from a patient with congenital indifference to pain was found to produce analgesia in the rat following intracerebroventricular injections. The analgesic effect was attenuated by pretreatment with naloxone suggesting the involvement of hyperactive endogenous opiate mechanisms in this patient.
摘要
在对一名先天性无痛觉患者的脑脊液进行脑室注射后，发现其能使大鼠产生镇痛作用。纳洛酮预处理可减弱这种镇痛效果，提示该患者体内存在活跃的内源性阿片机制。
Zotero 插件