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格雷夫斯病长期缓解患者的促甲状腺素受体抗体

Thyroid stimulating immunoglobulins in patients in long-term remission after Graves' disease.

作者信息

Bliddal H, Bech K, Kirkegaard C

出版信息

Horm Metab Res. 1984 Nov;16(11):602-5. doi: 10.1055/s-2007-1014861.

DOI:10.1055/s-2007-1014861
PMID:6210237
Abstract

Thyroid stimulating antibodies (TSAb) and thyrotropin binding inhibiting immunoglobulins (TBII) were measured in 32 patients with Graves' disease who had been in remission for at least two years after treatment was been stopped. Seventeen patients had been treated with antithyroid drugs, and 15 patients with 131Iodine. In the first group 3 of 17 patients had TSAb and one TBII, whereas in the second group 4 of 15 patients had TSAb and two TBII. One patient from each group had inhibiting TSAb. During the follow-up one patient from each group relapsed, whereas 5 patients from the second group developed myxoedema. No relationship between the clinical outcome and TSAb and TBII was found.

摘要

对32例格雷夫斯病患者进行了甲状腺刺激抗体(TSAb)和促甲状腺素结合抑制性免疫球蛋白(TBII)检测,这些患者在停止治疗后至少已缓解两年。17例患者接受了抗甲状腺药物治疗,15例患者接受了131碘治疗。在第一组17例患者中,3例有TSAb,1例有TBII;而在第二组15例患者中,4例有TSAb,2例有TBII。每组各有1例患者有抑制性TSAb。在随访期间,每组各有1例患者复发,而第二组有5例患者发生了黏液性水肿。未发现临床结局与TSAb和TBII之间存在关联。

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Thyroid stimulating immunoglobulins in patients in long-term remission after Graves' disease.格雷夫斯病长期缓解患者的促甲状腺素受体抗体
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Clinical value of a new TSH binding inihibitory activity assay using human TSH receptors in the follow-up of antithyroid drug treated Graves' disease. Comparison with thyroid stimulating antibody bioassay.采用人促甲状腺激素受体的新型促甲状腺激素结合抑制活性测定法在抗甲状腺药物治疗的格雷夫斯病随访中的临床价值。与促甲状腺激素刺激抗体生物测定法的比较。
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The prognostic value of parallel measurements of thyrotropin binding inhibiting immunoglobulins (TBII) and thyroid adenylate cyclase stimulating antibodies (TSAb) in Graves' disease after longterm antithyroid treatment.长期抗甲状腺治疗后,促甲状腺素结合抑制性免疫球蛋白(TBII)与甲状腺腺苷酸环化酶刺激抗体(TSAb)平行检测在格雷夫斯病中的预后价值。
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引用本文的文献

1
Thyroid-stimulating antibodies in patients with long-term remission of Graves' hyperthyroidism.格雷夫斯甲亢长期缓解患者的促甲状腺素抗体
Klin Wochenschr. 1986 Oct 31;64(21):1097-100. doi: 10.1007/BF01726868.
2
Prognostic value of thyroid stimulating antibodies and TSH-binding inhibiting immunoglobulins in the follow-up of Graves' disease.促甲状腺素抗体和促甲状腺素结合抑制性免疫球蛋白在格雷夫斯病随访中的预后价值。
Klin Wochenschr. 1985 Dec 16;63(24):1247-52. doi: 10.1007/BF01738449.
3
Clinical course and thyroid stimulating hormone (TSH) receptor antibodies during surgical treatment of Graves' disease.
格雷夫斯病手术治疗期间的临床病程及促甲状腺激素(TSH)受体抗体
World J Surg. 1992 Jul-Aug;16(4):647-52; discussion 652-3. doi: 10.1007/BF02067345.