Ginsburg C H, Falchuk Z M
Gastroenterology. 1982 Jul;83(1 Pt 1):1-9.
Impaired regulation of immune function may contribute to the abnormal immune responses associated with idiopathic inflammatory bowel disease. We examined the autologous mixed-lymphocyte culture in inflammatory bowel disease patients because this reaction may reflect self regulation of immune responses in vivo and results in activation of suppressor T cells in vitro. We also examined suppressor T-cell generation in two separate assays. In contrast to healthy and disease controls who had normal values, the autologous mixed-lymphocyte culture response was diminished in 44 of 51 (86%) patients with inflammatory bowel disease, independent of disease type, activity, or steroid therapy. Fourteen of 17 inflammatory bowel disease patients (83%) had decreased suppressor T-cell generation. These results show a distinct abnormality in autologous mixed-lymphocyte culture reactivity and in generation of suppressor cells in inflammatory bowel disease. Such impaired immune regulation may be partly responsible for the immunologic aberrations observed in patients with inflammatory bowel disease.
免疫功能调节受损可能导致与特发性炎症性肠病相关的异常免疫反应。我们检测了炎症性肠病患者的自体混合淋巴细胞培养，因为这种反应可能反映体内免疫反应的自我调节，并在体外导致抑制性T细胞的激活。我们还在两个独立的试验中检测了抑制性T细胞的生成。与健康对照组和疾病对照组（其值正常）相比，51例炎症性肠病患者中有44例（86%）的自体混合淋巴细胞培养反应减弱，与疾病类型、活动程度或类固醇治疗无关。17例炎症性肠病患者中有14例（83%）抑制性T细胞生成减少。这些结果表明，炎症性肠病患者的自体混合淋巴细胞培养反应性和抑制性细胞生成存在明显异常。这种免疫调节受损可能部分导致了炎症性肠病患者所观察到的免疫异常。
