移植到裸鼠体内的人口腔黏膜中的ATP酶阳性细胞。

ATP-ase positive cells in human oral mucosa transplanted to nude mice.

作者信息

Dabelsteen E, Kirkeby S

出版信息

Scand J Dent Res. 1981 Oct;89(5):433-5. doi: 10.1111/j.1600-0722.1981.tb01704.x.

DOI:10.1111/j.1600-0722.1981.tb01704.x

Abstract

A model to study the differentiation of human oral epithelium in vivo utilizing transplantation of human tissue to nude mice has been described. Previous studies have described the epithelial cells in this model. In this study we demonstrate that 8 d after transplantation, Langerhans cells, identified as ATP-ase positive dendritic cells, have almost disappeared from the transplanted epithelium whereas at day 21 after transplantation such cells were abundant. It is suggested that the ATP-ase positive cells which reappear in the transplanted epithelium are of mouse origin.

摘要

已经描述了一种利用将人体组织移植到裸鼠体内来研究人体口腔上皮细胞在体内分化的模型。先前的研究已经描述了该模型中的上皮细胞。在本研究中，我们证明移植后8天，被鉴定为ATP酶阳性树突状细胞的朗格汉斯细胞已几乎从移植的上皮中消失，而在移植后第21天，此类细胞大量存在。有人提出，在移植上皮中重新出现的ATP酶阳性细胞是小鼠来源的。