Perchalski R J
J Chromatogr. 1978 Jan 1;145(1):97-103. doi: 10.1016/s0378-4347(00)81671-0.
A previously published procedure for the gas chromatographic analysis of carbamazepine has been modified and expanded to allow simultaneous determination of phenylethylmalonamide, a metabolite of primidone. Internal standards that closely resemble each compound are used, and derivatives are made by reaction with dimethylformamide dimethylacetal. This change of internal standard for carbamazepine and the use of a commercial, pretested column-packing material eliminate the major pitfalls of the original method.
一种先前发表的卡马西平气相色谱分析方法已被修改和扩展，以允许同时测定扑米酮的代谢产物苯乙基丙二酰胺。使用与每种化合物非常相似的内标，并通过与二甲基甲酰胺二甲基缩醛反应制备衍生物。卡马西平内标的这种变化以及使用商业上预先测试过的柱填充材料消除了原方法的主要缺陷。
