Smolen J S, Chused T M, Novotny E A, Steinberg A D
J Immunol. 1982 Sep;129(3):1050-3.
The human autologous mixed lymphocyte reaction represents the proliferative response of T cells to determinants presented on autologous non-T cells. Purified T4+ cells vigorously proliferate in response to stimulation by either (B + null) cells or M phi, whereas purified T8+ cells proliferate very little without a source of help. Such help can be provided by mitomycin C-treated T4+ cells, which indicates that proliferation of T4+ cells is not necessary for the help. M phi suppress the human AMLR, as measured by the response of T cells to stimulation by (B + null) cells. The target of this M phi-induced suppression was found to be the T4+ inducer cell. In contrast to the suppressive effects of M phi on T4+ cells, M phi did not suppress T8+ cells. The available data suggest that the human AMLR is a two-part inducer circuit. One part can be stimulated preferentially by M phi and the other by (B + null) cells; however, M phi prevent activation of the (B + null) cell part of the circuit. These results may provide an explanation for the differential activities of different regulatory circuits without and also with antigenic stimulation.
人类自体混合淋巴细胞反应代表了T细胞对自体非T细胞所呈递决定簇的增殖反应。纯化的T4+细胞在受到（B细胞+裸细胞）或巨噬细胞刺激时会强烈增殖，而纯化的T8+细胞在没有辅助来源的情况下增殖很少。这种辅助可以由丝裂霉素C处理的T4+细胞提供，这表明T4+细胞的增殖对于辅助作用并非必要。巨噬细胞抑制人类自体混合淋巴细胞反应，这是通过T细胞对（B细胞+裸细胞）刺激的反应来衡量的。发现这种巨噬细胞诱导的抑制作用的靶点是T4+诱导细胞。与巨噬细胞对T4+细胞的抑制作用相反，巨噬细胞并不抑制T8+细胞。现有数据表明，人类自体混合淋巴细胞反应是一个由两部分组成的诱导回路。一部分可优先被巨噬细胞刺激，另一部分被（B细胞+裸细胞）刺激；然而，巨噬细胞会阻止回路中（B细胞+裸细胞）部分的激活。这些结果可能为不同调节回路在有无抗原刺激情况下的差异活性提供一种解释。
