Ransohoff R M, Dustoor M M
Clin Exp Immunol. 1983 Jul;53(1):67-75.
Polymyositis/dermatomyositis (PM/DM) is an autoimmune disorder of unknown aetiology. In order to study whether immunoregulatory abnormalities might be involved in this autoimmune state, we investigated the autologous mixed lymphocyte reaction (AMLR) and concanavalin A-induced suppressor cell function (Con A-induced suppression) in adult patients with primary PM/DM. We found the AMLR to be significantly depressed in patients; responsiveness could not be enhanced by increasing the numbers of non-T stimulator cells in culture, nor by varying the day on which cultures were harvested. Con A-induced suppression of T cell proliferative responses to mitogenic stimuli was normal. These findings implicate abnormal immunoregulation in the pathophysiology of PM/DM. Further, the dissociation of AMLR reactivity from Con A-inducible suppression suggests that events important for immunoregulatory competence may occur in the AMLR culture, despite the absence of an observed proliferative response.
多发性肌炎/皮肌炎（PM/DM）是一种病因不明的自身免疫性疾病。为了研究免疫调节异常是否可能参与这种自身免疫状态，我们调查了成年原发性PM/DM患者的自体混合淋巴细胞反应（AMLR）和伴刀豆球蛋白A诱导的抑制细胞功能（伴刀豆球蛋白A诱导的抑制作用）。我们发现患者的AMLR明显受到抑制；通过增加培养中非T刺激细胞的数量或改变收获培养物的天数，反应性均无法增强。伴刀豆球蛋白A诱导的对有丝分裂刺激的T细胞增殖反应的抑制作用是正常的。这些发现表明免疫调节异常参与了PM/DM的病理生理过程。此外，AMLR反应性与伴刀豆球蛋白A诱导的抑制作用的分离表明，尽管没有观察到增殖反应，但对免疫调节能力重要的事件可能在AMLR培养中发生。
