Mehta J, Runge W, Cohn J N, Carlyle P
J Lab Clin Med. 1978 Feb;91(2):272-89.
Acute myocardial necrosis was produced in 27 anesthetized dogs by repetitive DC 75 joule shock delivered with one electrode in the left ventricular cavity and the other on the left chest wall. A total of 1 shock/kg body weight delivered at 10 sec intervals resulted in discrete anterior wall necrosis of 7% to 31% (mean, 17.6%) of the mass of left ventricular myocardium. After some transient bradycardia, normal sinus rhythm was restored. Depression of left ventricular function 15 min after shock (rise in LVEDP from 4.0 +/- 1.5 to 17 +/- 2 mm Hg and fall in cardiac output from 2.29 +/- 0.24 to 1.82 +/- 0.12 L/min) recovered only slightly during the ensuing 2 hr. A significant correlation (r=0.85) was observed between the LVEDP at 2 hr after shock and the extent of necrosis determined histochemically and histologically at the time of sacrifice 3 hr after shock. Thus, in this form of acute myocardial damage, pump dysfunction is closely related to the area of necrosis.
在27只麻醉犬身上造成急性心肌坏死，方法是通过在左心室腔内置一个电极，在左胸壁外置另一个电极，重复施加75焦耳直流电休克。以10秒的间隔，按每千克体重施加1次休克，导致左心室心肌质量的7%至31%（平均17.6%）出现离散的前壁坏死。经过一些短暂的心动过缓后，恢复了正常窦性心律。休克后15分钟左心室功能降低（左心室舒张末期压力从4.0±1.5毫米汞柱升至17±2毫米汞柱，心输出量从2.29±0.24升/分钟降至1.82±0.12升/分钟），在随后的2小时内仅略有恢复。在休克后2小时的左心室舒张末期压力与休克后3小时处死时通过组织化学和组织学确定的坏死范围之间观察到显著相关性（r = 0.85）。因此，在这种急性心肌损伤形式中，泵功能障碍与坏死面积密切相关。
