Ewy G A, Taren D, Bangert J, McClung S, Hellman D A
Med Instrum. 1980 Jan-Feb;14(1):9-12.
To study the difference in myocardial damage produced by the same defibrillation energy delivered at frequent, low-energy discharges vs infrequent, high-energy discharges, experiments were performed on 48 dogs. In Part I, a total of 3000 Wsec energy was delivered; in Part II, a total of 600 Wsec was delivered; and in Parts III and IV, a total of 1800 Wsec was delivered. In half the dogs, the energy was delivered in three shocks within 135 sec. In the other half, the shocks were delivered by 10 smaller shocks at 15-sec intervals. The degree of myocardial damage assessed by ST-segment elevation on precordial mapping or necrotic index from gross and microscopic examination 4 days after the shocks showed no significant difference. However, the three high-energy shocks (600 to 100 Wsec) resulted in ventricular fibrillation or complete heart block in 33% (6 of 18) of the dogs. These arrhythmias were not observed in the animals receiving low-energy (60-, 200-, or 300-Wsec) discharges.
为研究在频繁低能量放电与不频繁高能量放电时相同除颤能量所产生的心肌损伤差异，对48只犬进行了实验。在第一部分，总共释放3000瓦秒能量；在第二部分，总共释放600瓦秒能量；在第三和第四部分，总共释放1800瓦秒能量。在一半的犬中，能量在135秒内分三次电击释放。在另一半犬中，电击以10次较小电击、间隔15秒的方式释放。通过胸前区心电图ST段抬高或电击后4天大体及显微镜检查的坏死指数评估的心肌损伤程度无显著差异。然而，三次高能量电击（600至100瓦秒）导致33%（18只中的6只）的犬发生室颤或完全性心脏传导阻滞。在接受低能量（60、200或300瓦秒）放电的动物中未观察到这些心律失常。
