De Backer G, Vincke J
Acta Cardiol. 1982;37(4):245-55.
The effect of Diltiazem, a calcium antagonist drug, were compared with those of placebo on exercise performance. Twenty four patients with exercise-inducible chronic stable angina pectoris were studied over a double-blind period of 8 weeks. The active product was generally well tolerated. Diltiazem was effective in increasing the anginal threshold, in decreasing the ST-segment depression at an identical submaximal workload and in increasing the time to termination of exercise. These results are in accordance with those of others but the mechanisms whereby these effects occur are unclear; the observed results suggest that peripheral effects are not primarily responsible for the drugs' efficacy.
将钙拮抗剂地尔硫䓬与安慰剂对运动能力的影响进行了比较。对24例运动诱发的慢性稳定型心绞痛患者进行了为期8周的双盲研究。活性产品总体耐受性良好。地尔硫䓬在提高心绞痛阈值、在相同次最大负荷下减少ST段压低以及延长运动终止时间方面有效。这些结果与其他人的结果一致，但这些作用发生的机制尚不清楚；观察到的结果表明外周效应并非药物疗效的主要原因。
