Pool P E, Seagren S C, Bonanno J A, Salel A F, Dennish G W
Chest. 1980 Jul;78(1 Suppl):234-8.
Although diltiazem has been shown to alleviate vasospastic angina pectoris, its effect on exercise-inducible chronic stable angina has not been objectively studied. Accordingly, the effect of diltiazem was studied in this condition with a placebo controlled double-blind randomized cross-over protocol at three dose levels (120, 180 and 240 mg/day) during graded treadmill exercise. Three end-points were evaluated: 1) time to onset of angina or fatigue if angina were eliminated; 2) time to 1 mm ST segment depression or fatigue if ST depression were eliminated; and 3) time to termination of exercise (2+ angina or fatigue). All end-points were prolonged at all dose levels. At the highest dose of 240 mg/day, time to onset angina or termination was prolonged from a placebo time of 8.0 +/ 0.9 to 9.8 +/- 0.9 minutes (p = < .001); time to ST depression or termination was prolonged from 7.8 +/- 0.9 to 9.1 +/- 0.8 minutes (p = .007); and time to termination was prolonged from 9.9 +/- 0.9 to 10.8 +/- 0.8 minutes (p = .02).
尽管地尔硫䓬已被证明可缓解血管痉挛性心绞痛，但其对运动诱发的慢性稳定型心绞痛的影响尚未得到客观研究。因此，采用安慰剂对照、双盲、随机交叉试验方案，在分级平板运动期间，于三个剂量水平（120、180和240毫克/天）研究了地尔硫䓬在此种情况下的作用。评估了三个终点指标：1）出现心绞痛或疲劳（若心绞痛消失）的时间；2）出现1毫米ST段压低或疲劳（若ST段压低消失）的时间；3）运动终止时间（2级以上心绞痛或疲劳）。在所有剂量水平下，所有终点指标均延长。在240毫克/天的最高剂量下，出现心绞痛或运动终止的时间从安慰剂组的8.0±0.9分钟延长至9.8±0.9分钟（p＜0.001）；出现ST段压低或运动终止的时间从7.8±0.9分钟延长至9.1±0.8分钟（p = 0.007）；运动终止时间从9.9±0.9分钟延长至10.8±0.8分钟（p = 0.02）。
