干燥综合征患者外周血中Ia阳性T细胞的增加与自体混合淋巴细胞反应的降低相关。
An increase in peripheral blood Ia-positive T cells in Sjögren's syndrome correlates with a decrease in the autologous mixed lymphocyte response.
作者信息
Sauvezie B, Miyasaka N, Charron D, Kielich C, Loeb J, Daniels T E, Talal N
出版信息
Clin Exp Immunol. 1982 Jul;49(1):50-8.
Abstract
The defective autologous MLR was studied in Sjögren's syndrome (SS) in relation to Ia+ cells as determined by reactivity with a monoclonal anti-human Ia antibody. By indirect immunofluorescence, the percentage of Ia+ T lymphocytes was increased in nine of 15 patients. There was no correlation with clinical features or drugs. The percentage of Ia+ T cells in the non-T cell preparations was normal. An inverse correlation was found between the percentage of Ia+ T cells and the proliferative response to autologous non-T cells. Removal of Ia+ T cells enhanced both the autologous MLR and the allogeneic MLR. Thus Ia+ T cells contain suppressor cells in the MLR, but this may not be the sole explanation for the defective autologous MLR.
摘要
针对干燥综合征（SS）中存在缺陷的自体混合淋巴细胞反应（MLR），研究了与通过单克隆抗人Ia抗体反应性所确定的Ia⁺细胞之间的关系。通过间接免疫荧光法，15例患者中有9例的Ia⁺T淋巴细胞百分比升高。这与临床特征或用药情况无关。非T细胞制剂中Ia⁺T细胞的百分比正常。发现Ia⁺T细胞百分比与对自体非T细胞的增殖反应之间呈负相关。去除Ia⁺T细胞可增强自体MLR和同种异体MLR。因此，Ia⁺T细胞在MLR中含有抑制细胞，但这可能不是自体MLR存在缺陷的唯一解释。
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本文引用的文献
1
SJOEGREN'S SYNDROME. A CLINICAL, PATHOLOGICAL, AND SEROLOGICAL STUDY OF SIXTY-TWO CASES.
Medicine (Baltimore). 1965 May;44:187-231.
2
Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization.
J Exp Med. 1980 Jan 1;151(1):91-100. doi: 10.1084/jem.151.1.91.
3
Ia antigen on peripheral blood mononuclear leukocytes in man. I. Expression, biosynthesis, and function of HLA-DR antigen non-T cells.
J Exp Med. 1980 Aug 1;152(2 Pt 2):99s-113s.
4
Two types of Ia-positive T cells. Synthesis and exchange of Ia antigens.
J Exp Med. 1980 Aug 1;152(2 Pt 2):89s-98s.
5
Ia antigen on the surface of a subfraction of T cells that bear Fc receptors for IgG.
J Immunol. 1980 Mar;124(3):1075-8.
6
Antigen-reactive T cells can be activated buy autologous macrophages in the absence of added antigen.
J Exp Med. 1981 Feb 1;153(2):476-81. doi: 10.1084/jem.153.2.476.
7
Decreased autologous mixed lymphocyte reaction in Sjögren's syndrome.
J Clin Invest. 1980 Nov;66(5):928-33. doi: 10.1172/JCI109960.
8
Ia antigen on peripheral blood mononuclear leukocytes in man. II. Functional studies of HLA-DR-positive T cells activated in mixed lymphocyte reactions.
J Exp Med. 1980 Aug 1;152(2 Pt 2):114s-126s.
9
The autologous mixed lymphocyte reaction in strains of mice with autoimmune disease.
J Immunol. 1980 Oct;125(4):1832-8.
10
T cells and macrophages involved in the autologous mixed lymphocyte reaction are required for the response to conventional antigen.
J Immunol. 1980 Sep;125(3):1374-9.
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