Beverley P C, Linch D C, Callard R E, Worman C P, Cawley J C
J Clin Immunol. 1982 Jul;2(3 Suppl):135S-141S.
A group of patients with neutropenia or erythroid aplasia associated with T cell proliferation were evaluated to assess the phenotype(s) and functions of T cells observed in these conditions. These patients have near normal numbers of helper/inducer cells but an excess of cells belonging to the suppressor/cytotoxic subset. The characteristic phenotype of these cells is E+, OKT3+, OKT1+1-, OKT8+, Fc gamma R+, and they frequently bear HLA-DR antigen. These cells respond poorly to T cell mitogens and will suppress the response of normal peripheral blood mononuclear cells to mitogens. They fail to suppress PWM-induced immunoglobulin synthesis. Although the natural killer activity in these patients is sometimes low, this subset of T cells possesses cytotoxic capability demonstrable in assays for antibody-dependent cell-mediated cytotoxicity. The evidence for a direct effect of the T cells on BFUE and CFUGM is poor.
对一组患有与T细胞增殖相关的中性粒细胞减少或红细胞生成障碍的患者进行了评估，以确定在这些情况下观察到的T细胞表型和功能。这些患者的辅助/诱导细胞数量接近正常，但属于抑制/细胞毒性亚群的细胞过多。这些细胞的特征性表型为E+、OKT3+、OKT1+1-、OKT8+、FcγR+，并且它们经常携带HLA-DR抗原。这些细胞对T细胞有丝分裂原反应不佳，并会抑制正常外周血单个核细胞对有丝分裂原的反应。它们不能抑制PWM诱导的免疫球蛋白合成。尽管这些患者的自然杀伤活性有时较低，但这一T细胞亚群在抗体依赖性细胞介导的细胞毒性检测中具有可证明的细胞毒性能力。T细胞对BFUE和CFUGM有直接作用的证据不足。
