Moss R L
J Muscle Res Cell Motil. 1982 Sep;3(3):295-311. doi: 10.1007/BF00713039.
The relationship between maximum shortening velocity (Vmax) and free calcium concentration has been studied in skinned single fibres from rabbit psoas and soleus muscles. At both 10 and 15 degrees C, Vmax measured in the psoas fibres was found to decrease by 40% when the pCa(-log[Ca2+]) was increased from 5.49 (maximally activating) to 6.21. Further decreases in Vmax were observed when the pCa was increased to 6.32. Vmax measured in soleus fibres at 15 degrees C also decreased when the Ca2+ concentration was lowered, though the magnitude of this effect was slightly less than in the psoas fibres. Thus, a distinct effect of Ca2+ upon Vmax has been shown to occur in mammalian skeletal muscle. The occurrence of this effect in both fast and slow muscle types may indicate that the underlying mechanism in the two cases is similar.
已对取自兔腰大肌和比目鱼肌的去膜单根肌纤维中最大缩短速度（Vmax）与游离钙浓度之间的关系进行了研究。在10℃和15℃时，当pCa（-log[Ca2+]）从5.49（最大激活状态）增加到6.21时，腰大肌纤维中测得的Vmax下降了40%。当pCa增加到6.32时，观察到Vmax进一步下降。在15℃时，当降低比目鱼肌纤维中的Ca2+浓度时，测得的Vmax也下降，尽管这种效应的幅度略小于腰大肌纤维。因此，已证明Ca2+对哺乳动物骨骼肌中的Vmax有明显影响。这种效应在快肌和慢肌类型中均出现，这可能表明两种情况下的潜在机制相似。
