[Primary structure of fibrinogen, its relation to conformation and function of the molecule].
作者信息
Lugovskoĭ E V
出版信息
Ukr Biokhim Zh (1978). 1982 Sep-Oct;54(5):578-94.
PMID:6215752
Abstract
Data available in literature are generalized for the amino acid sequence of three fibrinogen chains, their homology and a possibility for their common precursor to exist. The primary structure of resistant products of fibrinogen splitting by plasmin, compactness of their space organization and mutual arrangement in the intact molecule are described. The relation between the primary structure of fibrinogen and its high specificity as a thrombin substrate is traced. Evidence is considered concerning localization of active molecule centres to provide spontaneous polymerization of fibrin.
摘要
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