Kobel M, Creighton R E, Steward D J
Can Anaesth Soc J. 1982 Nov;29(6):593-9. doi: 10.1007/BF03007747.
Down's Syndrome (Trisomy 21, T21) occurs in approximately 0.15 per cent of live births. In addition to the stigmata of the syndrome, other congenital defects are frequently found in these patients. Cardiac lesions are particularly prominent. To determine the complications associated with anaesthesia and surgery we examined the records of 100 consecutive patients (58 males, 42 females) who underwent surgery with general anaesthesia during a two year period, from March 1978-March 1980. In addition to the cardiac lesions, the low birth weight of Trisomy 21 infants, increased susceptibility to infections, atlanto-occipital dislocation, and reduced central nervous system catecholamine levels might be expected to result in an increased incidence of complications. This study of 100 patients with Trisomy 21 (T21) indicates that the incidence of complications is low. However, the anaesthetist must understand the pathophysiology of T21 in order to provide optimal anaesthetic care.
唐氏综合征（21三体综合征，T21）在活产婴儿中的发生率约为0.15%。除了该综合征的特征外，这些患者还经常发现其他先天性缺陷。心脏病变尤为突出。为了确定与麻醉和手术相关的并发症，我们检查了1978年3月至1980年3月这两年期间连续100例接受全身麻醉手术患者（58例男性，42例女性）的记录。除了心脏病变外，21三体综合征婴儿出生体重低、易感染、寰枕关节脱位以及中枢神经系统儿茶酚胺水平降低，可能会导致并发症发生率增加。这项对100例21三体综合征（T21）患者的研究表明，并发症的发生率较低。然而，麻醉医生必须了解T21的病理生理学，以便提供最佳的麻醉护理。
