Smokovitis A, Auerswald W, Müller K, Clopath P, Binder B R
Haemostasis. 1982;12(3):256-61. doi: 10.1159/000214680.
In a strain of genetically hypercholesterolemic rats (RICO), developed from an albino mutant of Rattus norvegicus (Sprague-Dawley, Tif: RAIf, SPF) by selective breeding, the intimal plasminogen activator activity (PAA) at the nonbranching regions of the aorta was markedly lower than at the nonbranching regions of the aorta in the control strain (Sprague-Dawley). At the branching regions of the aorta the intimal PAA showed no difference between the two strains of rats. In another strain of rats (HBC; hyper-beta-cholesterolemic) with a slightly elevated level of total cholesterol in the blood, a high concentration of LDL-cholesterol and a low concentration of triglycerides, the intimal PAA showed no difference from that in the control strain (Sprague-Dawley) at the branching and nonbranching regions of the aorta. 6 weeks after a single injection of streptozotocin at a diabetogenic dose (45 mg/kg) into RICO rats and the control strain, the intimal PAA was found to be increased by 280% in RICO rats, but only by 140% in controls, compared to that in the corresponding nontreated rats.
在通过选择性育种从挪威大鼠（斯普拉格 - 道利，品系：RAIf，无特定病原体）的白化突变体培育出的遗传性高胆固醇血症大鼠品系（RICO）中，主动脉非分支区域的内膜纤溶酶原激活物活性（PAA）明显低于对照品系（斯普拉格 - 道利）主动脉非分支区域的活性。在主动脉分支区域，两品系大鼠的内膜PAA无差异。在另一品系大鼠（HBC；高β - 胆固醇血症）中，其血液中总胆固醇水平略有升高、低密度脂蛋白胆固醇浓度高且甘油三酯浓度低，在主动脉分支和非分支区域，内膜PAA与对照品系（斯普拉格 - 道利）无差异。以致糖尿病剂量（45mg/kg）向RICO大鼠和对照品系单次注射链脲佐菌素6周后，发现RICO大鼠的内膜PAA相较于相应未处理大鼠增加了280%，而对照品系仅增加了140%。
