Smokovitis A
Haemostasis. 1978;7(5):303-19. doi: 10.1159/000214273.
Histochemical studies of the aorta in newborn, young, and adult rats showed that the intima in the branching regions and at the beginning of the branches has a constantly increased plasminogen activator activity in comparison with the nonbranching regions. The aortic valve also shows constantly increased activator activity. The intimal activator activity is variable in the nonbranching regions, depending on the age and the anatomical area of the aorta. In young rats (20--30 days), the overall plasminogen activator activity in the aortic intima is higher than in adult rats (2--4 months), while the activity is variable in newborn rats. The intimal activator activity is generally higher in the thoracic aorta than in the abdominal aorta (in the nonbranching regions). The aortic wall has a low plasmin inhibitor capacity. The pattern of the endothelial plasminogen activator activity at different ages and anatomical areas of the aorta, in combination with the corresponding pattern of the aortic endothelial cell turnover, gives valuable information about the mechanism(s) of the production and normal (nonstressed) release of the endothelial plasminogen activator.
对新生、幼年和成年大鼠主动脉的组织化学研究表明，与非分支区域相比，分支区域及分支起始处的内膜纤溶酶原激活物活性持续增加。主动脉瓣的激活物活性也持续增加。在非分支区域，内膜激活物活性因年龄和主动脉的解剖区域而异。在幼年大鼠（20 - 30天）中，主动脉内膜的总体纤溶酶原激活物活性高于成年大鼠（2 - 4个月），而新生大鼠的活性则有所不同。在非分支区域，胸主动脉的内膜激活物活性通常高于腹主动脉。主动脉壁的纤溶抑制能力较低。主动脉不同年龄和解剖区域的内皮纤溶酶原激活物活性模式，与相应的主动脉内皮细胞更新模式相结合，为内皮纤溶酶原激活物的产生机制和正常（非应激）释放提供了有价值的信息。
