Hirsch C A, Messenger R J, Brannon J L
J Pharm Sci. 1978 Feb;67(2):231-6. doi: 10.1002/jps.2600670227.
Several fenoprofen salts were prepared to obtain the most acceptable form for an oral dosage formulation. Thermal analysis techniques were used to compare stabilities of the water of hydration in different salt forms and to assess the effects of the water of hydration on compatibility with propoxyphene and codeine salts. Photodegradation products of fenoprofen were isolated and identified, and their relevance to product formulation was evaluated.
制备了几种芬洛芬盐，以获得口服剂型中最适宜的形式。采用热分析技术比较不同盐形式中水合水的稳定性，并评估水合水对与丙氧芬和可待因盐相容性的影响。分离并鉴定了芬洛芬的光降解产物，并评估了它们与产品配方的相关性。
