在母体化合物吖啶存在的情况下对前药高氯酸7-乙酰吖啶鎓进行分析。
Analysis of the prodrug 7-acetylacroninium perchlorate in presence of the parent compound acronine.
作者信息
Hansen A B, Kreilgård B, Huang C H, Repta A J
出版信息
J Pharm Sci. 1978 Feb;67(2):237-9. doi: 10.1002/jps.2600670228.
PMID:621645
Abstract
Analysis of acronine and the prodrug acetylacroninium perchlorate in parenteral solutions is described. The unstable prodrug reacts quantitatively with the nucleophilic agent aniline by an unusual mechanism to form a phenylimino derivative of acronine. This derivative and acronine itself were determined by a spectrophotometric two-component method.
摘要
描述了对肠胃外溶液中阿克罗宁和前药高氯酸乙酰阿克罗宁鎓的分析。这种不稳定的前药通过一种不同寻常的机制与亲核试剂苯胺发生定量反应，形成阿克罗宁的苯基亚氨基衍生物。该衍生物和阿克罗宁本身通过分光光度双组分法进行测定。
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