循环免疫复合物在妊娠中的作用。

The role of circulating immune-complex in pregnancy.

作者信息

Kuramoto M, Okamura K, Hamazaki Y, Furukawa K, Suzuki M

出版信息

Tohoku J Exp Med. 1982 Sep;138(1):7-15. doi: 10.1620/tjem.138.7.

DOI:10.1620/tjem.138.7

Abstract

The circulating immune complexes (CIC) in pregnancy sera have been thought to be involved in immunosuppression and to be one cause of pre-eclampsia. We detected CIC in human pregnancy sera using Raji cell test. A significant positive correlation was observed between the titers of immune-complexes and the immunosuppression. Although there was no correlation between the titers of CIC and clinical symptoms of pre-eclampsia evaluated at 29 to 31 week, a strong correlation was observed between the titers of CIC at 29 to 31 week and clinical symptoms of pre-eclampsia evaluated just before delivery. These results suggest that CIC in pregnancy sera functions immunosuppressively and also causes pre-eclampsia. It is useful to measure CIC levels for predisposing pre-eclampsia.

摘要

妊娠血清中的循环免疫复合物（CIC）被认为与免疫抑制有关，是子痫前期的原因之一。我们使用Raji细胞试验检测了人妊娠血清中的CIC。免疫复合物滴度与免疫抑制之间存在显著正相关。虽然在孕29至31周评估时CIC滴度与子痫前期的临床症状之间没有相关性，但在孕29至31周时CIC滴度与分娩前评估的子痫前期临床症状之间存在强相关性。这些结果表明，妊娠血清中的CIC具有免疫抑制作用，也会导致子痫前期。测量CIC水平对于子痫前期的易感性评估是有用的。